- PII
- S3034605325040119-1
- DOI
- 10.7868/S3034605325040119
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 59 / Issue number 4
- Pages
- 105-114
- Abstract
- To increase the number of peptide-based drugs produced, an important task is to reduce time costs for the realization of technological stages. One of the longest, energy- and resource-consuming stages of production is vacuum freeze drying. Therefore, in this work we conducted experimental studies on the selection of temperature and time modes of vacuum freeze drying of peptide-based pharmaceuticals. As a result of the experiments, a mode was selected that provides the residual moisture content in the samples not more than 2.5%, no boiling in the first period of drying and minimal shrinkage. Also in the work mathematical modeling of vacuum freeze drying process was carried out using the software package Comsol Multiphysics (calculation of sublimation front motion in a single H5 vial).
- Keywords
- вакуумная сублимационная сушка тепло- и массоперенос кинетика сушки моделирование вычислительной гидродинамики режимы сушки пептиды
- Date of publication
- 07.02.2026
- Year of publication
- 2026
- Number of purchasers
- 0
- Views
- 7
References
- 1. Henninot A., Collins J.C., Nuss J.M. The Current State of Peptide Drug Discovery: Back to the Future? // J. Med. Chem. 2018. V. 61. № 4. P. 1382.
- 2. Fosgerau K., Hoffmann T. Peptide therapeutics: current status and future directions // Drug Discovery Today. 2015. V. 20. № 1. P. 122.
- 3. Giordano C. Marchiò M., Timofeeva E., Biagini G. Neuroactive peptides as putative mediators of antiepileptic ketogenic diets // Front. Neurol. 2014. P. 63.
- 4. T.M. Research [Электронный ресурс]: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2016. URL: https://www.pmewswire.com/news-releases/peptide-therapeutics-market--global-industry-analysis-size-share-growth-trends-and-forecast-2016---2024-300462607.html (дата обращения: 15.06.2025).
- 5. Rossino G. et al. Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era // Molecules. 2023. P. 38.
- 6. Diao L., Melbohm B. Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides // Clinical Pharmacokinetics. 2013. V. 52. P. 855.
- 7. Wang L. et al. Therapeutic peptides: current applications and future directions // Sig Transduct Target Ther. 2022. V. 48. № 7. P. 27.
- 8. Heljo V.P., Harju H., Hatampää T., Yohannes G., Juppo A.M. The effect of freeze-drying parameters and formulation composition on IgG stability during drying // European Journal of Pharmaceutics and Biopharmaceutics. 2013. V. 85. № 3. P. 752.
- 9. Kommineni N. Freeze-drying for the preservation of immunoengineering products // iScience. 2022. V. 25. № 10. P. 32.
- 10. Jameel F., Searles J. Development and Optimization of the Freeze-Drying Processes, in: Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals. 26 July 2010. p763.
- 11. Artusio F. Development of freeze-drying cycle for a peptide-based drug in trays // Proceedings of Eurodrying, Torino, Italy, July 10–12, 2019. P. 449.
- 12. Garcia-Amezquita L.E., Welti-Chanes J., Vergara-Balderas F., Bermudez-Aguirre D. Freeze-drying: The Basic Process // Encyclopedia of Food and Health. 2016. P. 104.
- 13. Kawasaki H., Shimamouchi T., Kimura Y. Recent Development of Optimization of Lyophilization Process // Journal of Chemistry. 2019. P. 14.
- 14. Claussen I.C., Ustad T.S., Simmen I., Walde P.M. Atmospheric Freeze Drying – A Review // Drying Technology. 2007. V. 25. № 7. P. 947.
- 15. Rybak K., Parniakov O., Samborska K., Wiktor A., Witrowa-Rajchert D., Nowacka M. Energy and Quality Aspects of Freeze-Drying Preceded by Traditional and Novel Pre-Treatment Methods as Exemplified by Red Bell Pepper // Sustainability. 2021. V. 3. P. 16.
- 16. Waghmare R.B., Choudhary P., Moses J.A., Chinnaswamy Anandharamakrishnan, Stapley Andrew G.F. Trends in Approaches to Assist Freeze-Drying of Food: A Cohort Study on Innovations // Food Reviews International. 2022. V. 38. P. 552.
- 17. Krishnan T. The Computational and Experimental Study of the Freeze-Drying Process for a Monoclonal Antibody // PhD thesis, University College London. 2021. P. 219.
- 18. Artusio F., Adami M., Barresi A.A., Fissore D., Frave M.C., Udrescu C.I., Pisano R. The Freeze-Drying of Pharmaceuticals in Vials Nested in a Rack System – Part II: Primary Drying Behaviour // Pharmaceutics. V. 15. 2023. P. 2570.
